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Biomecánica

Tissue engineering

This activity is based on the development of new techniques which prevent the implantation of synthetic devices with substitute function and promote the reconstruction or the tissue regeneration.

Description

This line of work has as its objective the development of new techniques which avoid the implantation of synthetic devices with a substitutive function and which promote the reconstruction or regeneration of tissue.

For this purpose, resorbable scaffolds of biomaterials structured in fibres of micro/nanometric dimensions are used as a cellular growth support: Poly-Lactic Acid (PLA), Poly-Lactide-co-glycolide (PLGA), Polycaprolactone (PCL).

The ITC has an electrospinning machine to generate simple support elements (scaffolds) for cell growth, such as 2D membranes of unorganized nanofiber from biopolymers in solution. These fibers, spun into sheets, provide a favorable substrate for adhesion and cell growth.

We also have a machine of new acquisition, which allows us to manufacture three-dimensional biopolymer scaffolds with organized fibers (some fibers of nanometric dimensions interlaced with other ones more resistant on a micrometric scale) of controlled geometry for reconstruction of bone, cartilage and blood vessels, which is the main objective of this line of work.

Results

The electrospinning process has been automated through the implementation of the positioning of the injection needle in a robotic manner and the process improvement: new rotary and flat collectors, the modification of perfusion pump, design and manufacture of a dual injection pump to carry out simultaneous electrospinning of two different polymer solutions and the implementation of a PC control panel to integrate and simplify the management of devices involved in the process of electrospinning.
We have also achieved to generate 2D membranes of unorganized nanofiber from biopolymers in solution, as well as manufacturing 3D biopolymer scaffolds with organized fibers in order to obtain, in short time, controlled geometries for bone reconstruction, cartilage and blood vessels.

Target Audience

The end user would be the hospital patient who needs a bone reconstruction or tissue regeneration, prescribed by the doctor. Currently the users of this technology are research groups.

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